A facile synthesis of new 1,2-dihydro-2λ5-[1,3]oxazolo[5, 4-d][1,3,2]diazaphosphinine derivatives starting from 2-benzoylamino-3, 3-dichloroacrvlonitrile

Abstract

Easily accessible 2-benzoylamino-3,3-dichloroacrylonitrile, when treated successively with primary amines, phosphorus pentachloride, sulfur dioxide, and various N- or S-nucleophiles, furnishes the corresponding derivatives of 1,2-dihydro-2λ5-[1,3]oxazolo[5,4-d][1,3,2]diazaphosphinine, a novel fused heterocycle. The structure of the compounds obtained is unequivocally confirmed by spectroscopic methods and X-ray diffraction analysis. © 2008 Wiley Periodicals, Inc.