Escalating problems with drug resistance continue to compromise the effectiveness of commercial antibiotics, necessitating the search for novel classes of antimicrobial agents. To circumvent problems with resistance, a multitarget single-pharmacophore approach has been employed to discover inhibitors that possess balanced activity against multiple target enzymes. In this chapter, we examine the application of computational techniques, in particular, structure-based drug design approaches, to design new dual-targeting antibacterial agents against bacterial topoisomerases. © 2012 Springer Science+Business Media, LLC.
CITATION STYLE
Nguyen, T. B., Wong, S. E., & Lightstone, F. C. (2012). Leveraging structural information for the discovery of New Drugs: Computational methods. Methods in Molecular Biology, 841, 209–234. https://doi.org/10.1007/978-1-61779-520-6_9
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