Dynamic axis-tuned cells in the monkey lateral prefrontal cortex during a path-planning task

Abstract

The lateral prefrontal cortex (lPFC) plays a crucial role in the cognitive processes known as executive functions, which are necessary for the planning of goal-directed behavior in complex and constantly changing environments. To adapt to such environments, the lPFC must use its neuronal resources in a flexible manner. To investigate the mechanism by which lPFC neurons code directional information flexibly, the present study explored the tuning properties and time development of lPFC neurons in male Japanese monkeys during a path-planning task, which required them to move a cursor to a final goal in a stepwise manner within a checkerboard-like maze. We identified “axis-tuned” cells that preferred two opposing directions of immediate goals (i.e., vertical and horizontal directions). Among them, a considerable number of these axis-tuned cells dynamically transformed from vector tuning to a single final-goal direction. We also found that the activities of axis-tuned cells, especially pyramidal neurons, were also modulated by the abstract sequence patterns that the animals were to execute. These findings suggest that the axis-tuned cells change what they code (the type of behavioral goal) as well as how they code (their tuning shapes) so that the lPFC can represent a large number of possible actions or sequences with limited neuronal resources. The dynamic axis-tuned cells must reflect the flexible coding of behaviorally relevant information at the single neuron level by the lPFC to adapt to uncertain environments.