There are many variations to the classical randomized controlled trial. These variations are utilized when, for a variety of reasons, the classical randomized controlled trial would be impossible, inappropriate, or impractical. Some of the variations are described in this chapter and include: equivalence and non-inferiority trials; crossover trials; N of 1 trials, case-crossover trials, and externally controlled trials. Large simple trials, and prospective randomized, open-label, blinded endpoint trials are discussed in another chapter.
CITATION STYLE
Glasser, S. P. (2014). Alternative interventional study designs. In Essentials of Clinical Research, Second Edition (pp. 75–90). Springer International Publishing. https://doi.org/10.1007/978-3-319-05470-4_4
Mendeley helps you to discover research relevant for your work.