Experimental study on the influence of sulfonamide drug residues from honey on biochemical parameters in lab rats

Abstract

The objective of the research was the study on the influence of five sulfonamides residues (sulfadiazine, sulfamethazine, sulfathiazole, sulfamethizole, and sulfadimethoxine) in bee honey administered on Wistar rats, by evaluating various biochemical parameters (urea, creatinine, uric acid, total bilirubin, direct bilirubin and transaminases). The biochemical parameters presented significant variations and the results confirmed the occurrence of known toxic effects when administering the five sulfonamides from bee honey in rats: liver dysfunction through the permeabilization of the hepatocyte membrane, and the impairment of hepato-biliary and renal functions.