Acute oropharyngeal palsy is associated with antibodies to GQ1b and GT1a gangliosides

Abstract

Three patients with acute oropharyngeal palsy had high titre anti-Gq1b and anti-GT1a IgG antibodies. No patients had ophthalmoplegia or ptosis. In all patients limb ataxia or areflexia were present without notable limb weakness. These patients describe an oropharyngeal variant of Guillain-Barre syndrome in terms of anti-GQ1b antibody reactivity and show that high titre anti-Qq1b antibodies, serologically indistinguishable from those found in Miller Fisher syndrome, can occur in a clinical setting without ophthalmoplegia. The anti-GQ1b and anti-GT1a antibody assays may be helpful tests when considering the differential diagnosis of acute oropharyngeal palsy.