Growth hormone in the tumor microenvironment

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Abstract

Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironment (TME) comprising epithelial cancer cells, cancer stem cells, non-tumorous cells, stromal cells, immune-inflammatory cells, blood and lymphatic vascular network, and extracellular matrix. We review reports and present a hypothesis that postulates the involvement of growth hormone (GH) in field cancerization. We discuss GH contribution to TME, promoting epithelial-to-mesenchymal transition, accumulation of unrepaired DNA damage, tumor vascularity, and resistance to therapy.

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Chesnokova, V., & Melmed, S. (2019). Growth hormone in the tumor microenvironment. Archives of Endocrinology and Metabolism. Sociedade Brasileira de Endocrinologia e Metabologia. https://doi.org/10.20945/2359-3997000000186

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