Formulation development and evaluation of Telmisartan Nanoemulsion

Abstract

Available online on: 15.06.2017@http://ijrdpl.com http://dx. ABSTRACT:The aim of the present study was to development of oral nanoemulsion formulation of telmisartan belong to BCS class 2nd, It have low solubility and low permeability. Therefore, oral nanoemulsion containing Telmisartan was prepared to increase its solubility and bioavailability rate. The o/w nanoemulsion was prepared by screening the excipients from the nanoemulsion region of pseudo-ternary phase diagram. Oleic acid optimized as an oil phase based on higher solubility study. Surfactant (Tween 80) and co-surfactant (PEG 200) were mixed (Smix) in different volume ratios (1:1, 1:2, 1:3, 1:4, 2:1, 3:1..). The optimized formulation containing Oleic acid (13.6%), Tween 80 (23.9%), PEG 200 (7.9%) and Methanol (54.6%) as oil, surfactant, co-surfactant and aqueous phase in Smix was prepared. Formulated nanoemulsions has to be evaluated for UV, FTIR, in vitro drug release, viscosity, particle size, product stability at accelerated conditions compared to the conventional formulation. Optimized oral nanoemulsion showed increase bioavailability.