Tumor growth is restricted to approximately 2∈μm diameters by simple dissociation of nutrients and oxygen. Hence, tumors require the formation of new blood vessels for further growth progression. This process is referred to as tumor neo-angiogenesis. The process of tumor neo-angiogenesis is directed by complex bidirectional interactions between the tumor and the vessels, and creates a favorable microenvironment for angiogenesis. The tumor vessel system not only facilitates tumor growth by providing nutrients and oxygen but also functions as a convenient route for metastasis. A group of small cytokine-like molecules called chemokines have been shown to participate in angiogenesis under homeostatic and neoplastic conditions. This review summarizes their role in tumor-associated angiogenesis. © 2010 Springer-Verlag Berlin Heidelberg.
CITATION STYLE
Homey, B., Hippe, A., & Mueller-Homey, A. (2010). Chemokines. Recent Results in Cancer Research. https://doi.org/10.1007/978-3-540-78281-0_4
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