Synthesis and biological evaluation of ebselen and its acyclic derivatives

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Abstract

Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significant GSH Px-like activity, which are slightly higher than that of ebselen. The peroxynitrite scavenging activity showed that the acyclic allylseleno 4c was five times more potent than ebselen. © 2003 Pharmaceutical Society of Japan.

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Chang, T. C., Huang, M. L., Hsu, W. L., Hwang, J. M., & Hsu, L. Y. (2003). Synthesis and biological evaluation of ebselen and its acyclic derivatives. Chemical and Pharmaceutical Bulletin, 51(12), 1413–1416. https://doi.org/10.1248/cpb.51.1413

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