Immunogenicity of Therapeutic Proteins

Abstract

Therapeutic proteins are potent medications that have shown substantial promise in treating a wide range of illnesses and conditions. Immunogenicity is a unique obstacle that must be overcome when dealing with protein therapy. The immune response is triggered when there is a change in the structure of the protein, which may occur because of posttranslational changes such as the administration, storage, or manufacturing process of the product. The structure of the protein may affect immunotolerance; for example, low-abundance proteins have a lower overall tolerance. Antidrug antibodies (ADAs) may influence the pharmacokinetics, pharmacodynamics, and efficacy of therapeutic proteins. When it comes to the development of ADAs, one of the primary sources of concern is the interaction that therapeutic proteins have with endogenous proteins. In this chapter, we discuss the significant elements associated with the immunogenicity of therapeutic proteins.