Interleukin-38 (IL-38), a new cytokine of interleukin-1 family (IL-1F), is expressed in the human heart, kidney, skin, etc. Recently, new evidence indicated that IL-38 is involved in the process of different autoimmune diseases. Autoimmune diseases are a cluster of diseases accompanied with tissue damage caused by autoimmune reactions, including rheumatoid arthritis (RA), psoriasis, etc. This review summarized the links between IL-38 and autoimmune diseases, as well as the latest knowledge about the function and regulatory mechanism of IL-38 in autoimmune diseases. Especially, this review focused on the differentiation of immune cells and explore future prospects, such as the application of IL-38 in new technologies. Understanding the function of IL-38 is helpful to shed light on the progress of autoimmune diseases.
CITATION STYLE
Han, M. M., Yuan, X. R., Shi, X., Zhu, X. Y., Su, Y., Xiong, D. K., … Wang, J. N. (2021, September 2). The Pathological Mechanism and Potential Application of IL-38 in Autoimmune Diseases. Frontiers in Pharmacology. Frontiers Media S.A. https://doi.org/10.3389/fphar.2021.732790
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