Quantitative estimation for impact of genomic features responsible for 5′ and 3′ UTR formation in human genome

Abstract

UnTranslated Regions (UTRs) are part of messenger ribonucleic acid (mRNA) that do not undergo protein translation mechanism but plays an important role in translation control. Various genomic and non genomic features are responsible for controlling the translation. We have attempted to find various genomic features and their information content that are contributing to the length of UTRs. With the increase in length of UTRs, the translation process becomes slower resulting into less protein output. In this study results revealed that as length of 5′ UTR and 3′ UTR increase the information content of the sequence also increase but it becomes stable at longer UTR. Trimeric features are having more information content as compared to Dimeric features. As length of UTR increase the entropy of the information increases but after certain length it becomes stable. As 5′ UTR length increases the GC content decreases while AT increases and it is opposite in 3′ UTRs. Some genomic features like CG, TAA, CGT, CGC, CCG, CGG, ACG are having correlation <0.70 where as features like CT, TC, AC, CA, GT, GA. ACT, CAT, CTT, TCA, TGA are having correlation >0.90.