Evaluation of delayed treatment of focal cerebral ischemia with three selective k-opioid agonists in cats

Abstract

Background and Purpose The purpose of this study was to determine the therapeutic efficacy of three K-opioid agonists used for delayed treatment of experimental focal cerebral ischemia. Methods Forty halothane-anesthetized cats underwent permanent occlusion of the right intracranial internal carotid, middle cerebral, and anterior cerebral arteries via a transorbital, microsurgical approach. Six hours after occlusion, animals received a blinded bolus injection, and a subcutaneous osmotic pump was implanted to provide continuous release for 7 days. The injection and pump contained either saline or one of three K-agonists: dynorphin. © 1994 American Heart Association, Inc.