Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122

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Abstract

The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an East Asian-specific Y-chromosome haplogroup (O3-M122) in 2,332 individuals from diverse East Asian populations. Our results indicate that the O3-M122 lineage is dominant in East Asian populations, with an average frequency of 44.3%. The microsatellite data show that the O3-M122 haplotypes in southern East Asia are more diverse than those in northern East Asia, suggesting a southern origin of the O3-M122 mutation. It was estimated that the early northward migration of the O3-M122 lineages in East Asia occurred ∼25,000-30,000 years ago, consistent with the fossil records of modern humans in East Asia. © 2005 by The American Society of Human Genetics. All rights reserved.

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Shi, H., Dong, Y. L., Wen, B., Xiao, C. J., Underbill, P. A., Shen, P. D., … Su, B. (2005). Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122. American Journal of Human Genetics, 77(3), 408–419. https://doi.org/10.1086/444436

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