BeadArray™ technology: Enabling an accurate, cost-effective approach to high-throughput genotyping

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Abstract

The Human Genome Project has opened the door to personalized medicine, provided that human genetic diversity can be analyzed in a high-throughput and cost-effective way. Illumina has developed a genotyping system that combines very high throughput and accuracy with low cost per SNP analysis. The system uses our BeadArray™ platform, a high level of multiplexing, and modular, scalable automation to meet the requirements for cost-effective, genome-wide linkage disequilibrium studies. As implemented in a high-throughput genotyping service facility at Illumina, the system has a current capacity of one million SNP assays per day and is easily expandable. Each SNP call is associated with a quality score that correlates with accuracy.

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Oliphant, A., Barker, D. L., Stuelpnagel, J. R., & Chee, M. S. (2002). BeadArrayTM technology: Enabling an accurate, cost-effective approach to high-throughput genotyping. BioTechniques, 32(6 SUPPL.). https://doi.org/10.2144/jun0207

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