Hypoglossal motoneurons (HMs) receive serotonergic innervations from medullary raphe neurons and produce rhythmic discharge patterns closely associated with respiratory rhythm generated in the pre-Bötzinger complex (pBC). HM activity is subject to modulation by numerous factors including serotonin (5-HT), TRH, norepinephrine (NE), substance P (SP), pH, multiple protein kinases and phosphatases. In this present work, we introduce a computational HM model that facilitates the investigation of how neuromodulatory factors. such as 5-HT and pH, can affect HM activities. © 2008 Springer Science+Business Media, LLC.
CITATION STYLE
Tsao, T. H. B., & Butera, R. J. (2008). Computational model of task channels and pkc-pathway dependent serotonergic modulatory effects in respiratory-related neurons. In Advances in Experimental Medicine and Biology (Vol. 605, pp. 382–386). https://doi.org/10.1007/978-0-387-73693-8_67
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