microRNAs (miRNAs) are a class of endogenous short, non-coding RNAs that regulate a multitude of genes at the post-transcriptional level. miR-199, which is a highly conserved miRNA family, consists of miR-199a and miR-199b. Researchers mainly focused on miR-199a over the past few years. Functional studies have demonstrated that mature miR-199a is a key player in the maintenance of normal homeostasis and in the regulation of disease pathogenesis. Here, we summarize the biological functions of miR-199a and review recent research on its roles in the physiological processes of cancer cells, such as proliferation, migration, invasion, apoptosis, autophagy and glycometabolism.
CITATION STYLE
Wang, Q., Ye, B., Wang, P., Yao, F., Zhang, C., & Yu, G. (2019). Overview of microRNA-199a regulation in cancer. Cancer Management and Research. Dove Medical Press Ltd. https://doi.org/10.2147/CMAR.S231971
Mendeley helps you to discover research relevant for your work.