Cyclosporin A (CsA) has been shown by our laboratory and others to be neuroprotective in the experimental animal model of traumatic brain injury. However, we found that the intrathecal administration resulted in a concomitant increase of brain edema. The aim of this study was to assess whether intravascular administration may also influence brain edema formation. This project includes two independent series in which different doses of CsA were intravenously given to Sprague-Dawley rats of each group. In the first series, the animals were exposed to focal brain injury by a controlled cortical impact (CCI, 6 m/sec, 3 mm depth) and randomized into the following two groups.
CITATION STYLE
Marmarou, A., Fukui, S., Signoretti, S., & Dunbar, J. G. (2003). The effect of Cyclosporin A on brain edema formation following experimental cortical contusion. Acta Neurochirurgica, Supplementum, (86), 301–303. https://doi.org/10.1007/978-3-7091-0651-8_65
Mendeley helps you to discover research relevant for your work.