Apoptotic PET Imaging of Rat Pulmonary Fibrosis With [18F]ML-8

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Abstract

Objective: To investigate the value of 2-(3-[18F]fluoropropyl)-2-methyl-malonic acid ([18F]ML-8) positron emission tomography (PET) imaging of rat pulmonary fibrosis. Methods: Male Sprague-Dawley rats were divided into 2 groups, including pulmonary fibrosis model group and control group. The rat model was established by an intratracheal instillation of bleomycin (BLM). Control rats were treated with saline. Positron emission tomography/computed tomography (CT) with [18F]ML-8 or 18F-fluorodeoxyglucose ([18F]FDG) was performed on 2 groups. After PET/CT imaging, lung tissues were collected for histologic examination. Data were analyzed and comparisons between 2 groups were performed using Student t test. Results: Bleomycin-treated rats showed a higher lung uptake of [18F]ML-8 than control rats (P

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Xiong, Y., Nie, D., Liu, S., Ma, H., Su, S., Sun, A., … Tang, G. (2018). Apoptotic PET Imaging of Rat Pulmonary Fibrosis With [18F]ML-8. Molecular Imaging, 17. https://doi.org/10.1177/1536012118795728

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