Success rate of collagen gel droplet-embedded culture drug sensitivity test in colorectal cancer: Are antibiotics a prerequisite for specimen irrigation?

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Abstract

The collagen gel droplet-embedded culture drug sensitivity test (CD-DST) is one of the best chemosensitivity tests owing to its high success rate. However, CD-DST is often a culture method, and contamination is a serious problem, especially in the case of colorectal cancer, which is contaminated by enteric bacteria. It has been reported that the success rate of CDDST is 64.0% in the case of colorectal cancer. Therefore, the sampling and washing of specimens before culture are extremely important. By washing specimens carefully with normal saline containing antibiotics, we achieved a success rate of 85.3% in the case of colorectal cancer. To improve the success rate, we started specimen irrigation with a large amount of normal saline in January 2007. As a result, a success rate exceeding 90% was acquired. For the success of CD-DST for colorectal cancer, it is important to irrigate specimens many times with a large amount of normal saline.

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Yamada, T., Kan, H., Matsumoto, S., Kanazawa, Y., Koizumi, M., Sasaki, J., … Uchida, E. (2012). Success rate of collagen gel droplet-embedded culture drug sensitivity test in colorectal cancer: Are antibiotics a prerequisite for specimen irrigation? Journal of Nippon Medical School, 79(2), 163–165. https://doi.org/10.1272/jnms.79.163

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