Radionuclide Generator Systems Represent Convenient Production Systems to Provide Therapeutic Radionuclides

Abstract

In addition to the key roles which research reactors and accelerators play in the direct availability of radioisotopes for therapy at dedicated production sites, a third common mode for availability is the on-demand in-house elution of daughter radioisotopes from radioisotope generator production systems. The parent specie for such generator systems are generally either reactor- or accelerator-produced. In this chapter, the concepts associated with the fabrication and use of radionuclide generators which provide therapeutic radioisotopes are described, and key generator systems of current or expected interest are described in detail.