Absolute measurements of water content using magnetic resonance imaging: Preliminary findings in an in vivo focal ischemic rat model

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Abstract

Using a magnetic resonance (MR) imaging method, absolute measurements of in vivo brain water content were obtained in 15 male Long Evans rats that underwent a 90-min focal cerebral ischemia. A strong linear relationship (r = 0.80) with a slope of 1 was observed when correlating MR-measured water content to that obtained with the ex vivo wet/dry measurements. This effective spin-density-based method is the first-reported in vivo absolute quantification of brain tissue water content associated with a pathophysiological state and preliminary findings suggest that a noninvasive measurement of brain water content can be obtained with MRI.

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Venkatesan, R., Lin, W., Gurleyik, K., He, Y. Y., Paczynski, R. P., Powers, W. J., & Hsu, C. Y. (2000). Absolute measurements of water content using magnetic resonance imaging: Preliminary findings in an in vivo focal ischemic rat model. Magnetic Resonance in Medicine, 43(1), 146–150. https://doi.org/10.1002/(SICI)1522-2594(200001)43:1<146::AID-MRM18>3.0.CO;2-L

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