DBS for obsessive-compulsive disorder

Abstract

According to Diagnostic and Statistical Manual of Mental disorders, fifth edition (DSM-V), Obsessive compulsive disorder Obsessive compulsive disorder (OCD) is characterized by persistent obsessions Obsession with intrusive thoughts leading to severe generalized anxiety and/or compulsions Compulsion in the form of repetitive tasks to relieve this distress. OCD is often associated with depression and other co-morbidities. There is also an increase in the incidence of suicidal ideation and suicide among patients with OCD. OCD is a chronic and severe disabling heterogeneous disorder that has a significant impact on the life of patients and their families with public health consequences. It affects approximately 2–3% of population in the United States and worldwide and is the 10th leading cause of disability worldwide. OCD affects both genders equally. Pharmacological [Selective Serotonin reuptake Serotonin reuptake inhibitors (SSRIs)] and non-pharmacological therapies such as cognitive behavior therapy (CBT) are the first line treatment options in patients with medical refractory OCD. These modalities are effective in approximately 50% of patients with 40–60% reduction in OCD symptoms. However, 10–25% of these refractory patients have persistent OCD symptoms despite aggressive pharmacotherapy and behavior therapy.