One-pot synthesis of fused 3,4-dihydropyrimidin-2(1 H )-ones and thiones using a novel ionic liquid as an efficient and reusable catalyst: Improved protocol conditions for the Biginelli-like scaffolds

Abstract

A novel ionic liquid with multi-SO 3 H groups has been found to be an efficient acid catalyst for the one-pot three-component synthesis of fused 3,4-dihydropyrimidin-2(1 H )-ones and thiones under solvent free conditions. Good yields, short reaction times, straight forward workup, reusability of the catalyst and green conditions are the most obvious advantages of this methodology. Copyright © by Walter de Gruyter.