Neuropsychological impairments in people with schizophrenia or bipolar disorder and their unaffected relatives

128Citations
Citations of this article
119Readers
Mendeley users who have this article in their library.

Abstract

Background: Neuropsychological abnormalities in schizophrenia are well replicated and are present in unaffected relatives. Cognitive findings in bipolar disorder are less clearly established. Aims: To examine the possibility that these abnormalities may provide a means by which the disorders might be separated and to clarify the associations of phenotypic expression and genetic liability. Method: A neuropsychological test battery was administered to 50 control participants, 74 patients and 76 unaffected relatives recruited for the study. Patients included those with schizophrenia from families affected by schizophrenia alone, those with bipolar disorder from families affected by bipolar disorder alone and those with bipolar disorder from families affected by both disorders. Unaffected relatives were also recruited. Results: Current, verbal and pre-morbid IQ were impaired in people with schizophrenia and in their close relatives. Memory was impaired in all patient and relative groups. Psychomotor performance and performance IQ were impaired in patients, regardless of diagnosis. Conclusions: This study finds evidence that intellectual abnormalities are related to a genetic liability to schizophrenia. Abnormalities of memory appear to be related to an increased liability to psychosis in general. No impairment was specific to bipolar disorder.

References Powered by Scopus

A rating scale for depression

28499Citations
N/AReaders
Get full text

The positive and negative syndrome scale (PANSS) for schizophrenia

18196Citations
N/AReaders
Get full text

A rating scale for mania: Reliability, validity and sensitivity

7358Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Cognitive endophenotypes of bipolar disorder: A meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives

835Citations
N/AReaders
Get full text

Overlooking the obvious: A meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia

728Citations
N/AReaders
Get full text

A Meta-Analytic Investigation of Neurocognitive Deficits in Bipolar Illness: Profile and Effects of Clinical State

340Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

McIntosh, A. M., Harrison, L. K., Forrester, K., Lawrie, S. M., & Johnstone, E. C. (2005). Neuropsychological impairments in people with schizophrenia or bipolar disorder and their unaffected relatives. British Journal of Psychiatry, 186(MAY), 378–385. https://doi.org/10.1192/bjp.186.5.378

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 42

48%

Researcher 22

25%

Professor / Associate Prof. 19

22%

Lecturer / Post doc 5

6%

Readers' Discipline

Tooltip

Psychology 34

42%

Medicine and Dentistry 28

35%

Neuroscience 11

14%

Agricultural and Biological Sciences 8

10%

Save time finding and organizing research with Mendeley

Sign up for free