Effects of short-Term exposure to head-down tilt on cerebral hemodynamics: A prospective evaluation of a spaceflight analog using phase-contrast MRI

Abstract

Alterations in cerebral hemodynamics in microgravity are hypothesized to occur during spaceflight and could be linked to the Visual Impairment and Intracranial Pressure syndrome. Head-down tilt (HDT) is frequently used as a ground-based analog to simulate cephalad fluid shifts in microgravity; however, its effects on cerebral hemodynamics have not been well studied with MRI techniques. Here, we evaluate the effects of 1) various HDT angles on cerebral arterial and venous hemodynamics; and 2) exposure to 1% CO2 during an intermediate HDT angle (-12°) as an additional space-related environmental factor. Blood flow, cross-sectional area (CSA), and blood flow velocity were measured with phase-contrast MRI in the internal jugular veins, as well as the vertebral and internal carotid arteries. Nine healthy male subjects were measured at baseline (supine, 0°) and after 4.5 h of HDT at-6°,-12° (with and without 1% CO2), and-18°. We found a decrease in total arterial blood flow from baseline during all angles of HDT. On the venous side, CSA increased with HDT, and outflow decreased during-12° HDT (P = 0.039). Moreover, the addition of 1% CO2 to-12° HDT caused an increase in total arterial blood flow (P = 0.016) and jugular venous outflow (P < 0.001) compared with-12° HDT with ambient atmosphere. Overall, the results indicate decreased cerebral blood flow during HDT, which may have implications for microgravity-induced cerebral hemodynamic changes.