Abstract
Two 27C hydroperoxysterols, 7β-hydroperoxycholesterol (1) and its stereoisomer 7α-hydroperoxycholesterol (2), were isolated from the lipophilic extracts of a Formosan tunicate belonging to the genus Eudistoma. The structures of sterols 1 and 2 were elucidated on the basis of extensive spectral data analyses. Cytotoxicity of sterols 1 and 2 against a limited panel of cancer cell lines is also described. Sterol 1 show weak inhibitory effects on human neutrophil elastase release. © 2007 Pharmaceutical Society of Japan.
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Sung, P. J., Lin, M. R., Chen, J. J., Lin, S. F., Wu, Y. C., Hwang, T. L., & Fang, L. S. (2007). Hydroperoxysterols from the tunicate Eudistoma sp. Chemical and Pharmaceutical Bulletin, 55(4), 666–668. https://doi.org/10.1248/cpb.55.666
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