Angioedema

Abstract

Core Messages: Angioedema without weals is a distinct clinical pattern with different etiologies. It may require a management different from that of angioedema with weals. Histaminergic angioedema in chronic urticaria, allergic reactions, and physical urticarias develops rapidly and improves on epinephrine, corticosteroids, and antihistamines. In contrast, ACEI-associated angioedema, hereditary angioedema, and some cases of idiopathic angioedema are thought to be mediated by bradykinin; progress less rapidly; and respond poorly to epinephrine, steroids, and antihistamines. ACEI-induced angioedema may occur several years after the start of treatment. Patients of Afro-Carribean origin, those with hereditary or acquired angioedema, ACE inhibitor associated cough, and also immunocompromised cardiac and renal transplant patients are at increased risk of developing ACEI-induced angioedema. © 2010 Springer-Verlag Berlin Heidelberg.