Human immunodeficiency virus type 1 (HIV-1)- and Epstein-Barr virus- specific cytotoxic T lymphocyte precursors exhibit different kinetics in HIV- 1-infected persons

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Abstract

The frequencies of human immunodeficiency virus type 1 (HIV-1) Gag- and Epstein-Barr virus (EBV)-specific cytotoxic T lymphocyte precursors (CTLp) were studied longitudinally in peripheral blood mononuclear cells from 9 HIV- 1-infected persons. By antigen-specific stimulation, HIV-1 Gag-specific CTLp were detected in vitro throughout the coarse of HIV-1 infection, even after the onset of overt disease. In 4 patients, however, HIV-1 Gag-specific CTLp frequencies declined over time in the presence of maintained EBV-specific CTLp. This decline was correlated with decreasing CD4 (r = .38; P < .05) and CDg (r = .75; P < .001) cell numbers. The maintenance of EBV-specific CTLp in patients with low CD4 cell numbers indicated that EBV-specific CTL-mediated immunity may remain longer unaffected by HIV-1-induced immune dysfunction. Consistent with this observation, the growth of EBV-specific CTL could be supported in vitro by EBV-infected lymphoblastoid B cell lines, independent of both CD4 cells and exogenous cytokines.

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CITATION STYLE

APA

Geretti, A. M., Dings, M. E. M., Van Els, C. A. C. M., Van Baalen, C. A., Wijnholds, F. J., Borleffs, J. C. C., & Osterhaus, A. D. M. E. (1996). Human immunodeficiency virus type 1 (HIV-1)- and Epstein-Barr virus- specific cytotoxic T lymphocyte precursors exhibit different kinetics in HIV- 1-infected persons. Journal of Infectious Diseases, 174(1), 34–45. https://doi.org/10.1093/infdis/174.1.34

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