Purpose: To identify an immunohistochemical pattern of epithelial markers in granular, lattice and Avellino corneal dystrophies. Methods: Twenty-two corneal buttons, diagnosed as lattice (17), Avellino (4) and granular (1) underwent immunohistochemical studies of cytokeratins (CKs) on paraffin-embedded sections (group I). Monoclonal antibodies for pan-CK (AE1/AE3) and CKs 3/12, 5/6, 8, 18 and 19 were used. Twenty-two normal corneas were used as the control (group II). Results: Six lattice and 2 Avellino cases of group I stained positively with anti-CK 3/12 in corneal epithelium and areas of corneal stroma deposits. One of these cases of lattice was positive for anti-pan-CK (AE1/AE3) also in the epithelium and areas of corneal stroma deposits with a similar pattern. None of the controls (group II) revealed any staining in corneal stroma. All disease and control cases (groups I and II) revealed positive staining in corneal epithelium. Conclusion: AE1/AE3 and CK 3/12 anti-CK positive markers in the stromal deposits of lattice and Avellino dystrophies may suggest an epithelial genesis of the disease.
CITATION STYLE
Coutinho, A. B., De Freitas, D., Filho, J. P. D. S., Corrêa, Z. M. S., Odashiro, A. N., & Burnier, M. N. (2011). Cytokeratin expression in corneal dystrophies. Arquivos Brasileiros de Oftalmologia, 74(2), 118–122. https://doi.org/10.1590/S0004-27492011000200010
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