The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits

Abstract

Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of these issues is discussed, providing an initial framework for complex cross study design and planning. © 2013 The Author(s).