Purpose: To compare the visual, refractive and topographic outcomes of standard and accelerated corneal collagen cross-linking (CXL) in pediatric keratoconus patients. Methods: Prospective, comparative observational study on 68 eyes of 35 pediatric kerato-conus patients (<18 years). Patients were classified into two groups, group (I) included 34 eyes and received standard “Epi-Off” CXL (3 mW/cm2, 30 min.) and group (II) included 34 eyes and received accelerated “Epi-Off” CXL (9 mW/cm2, 10 min.). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), spherical equivalent (SE), simulated keratometry (Sim K-1, Sim K-2, K-max, K-mean), cylindrical (CYL), pachymetry and Q-value were evaluated preoperatively and for 3 years postoperatively. Results: Postoperative UDVA and CDVA did not significantly change in both groups after 3 years. Postoperative SE was increased significantly in accelerated CXL (p=0.012) with no significant change in the postoperative cylinder in both procedures. Standard CXL had greater “significant” effect in decreasing Sim K-1, K-max and K-mean. The mean reduction in postoperative corneal pachymetry (at thinnest location) was significant in standard CXL (18.4 μm) (p=0.001). No significant change was noticed in postoperative Q-value. Conclusion: Standard and accelerated CXL protocols are efficient in pediatric keratoconus management with better outcomes in the standard procedure.
CITATION STYLE
Amer, I., Elaskary, A., Mostafa, A., Hazem, H. A., Omar, A., & Abdou, A. (2020). Long-term visual, refractive and topographic outcomes of “epi-off” corneal collagen cross-linking in pediatric keratoconus: Standard versus accelerated protocol. Clinical Ophthalmology, 14, 3747–3754. https://doi.org/10.2147/OPTH.S275797
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