Group II introns are mobile genetic elements that self-splice and retrotranspose into DNA and RNA. They are considered evolutionary ancestors of the spliceosome, the ribonucleoprotein complex essential for pre-mRNA processing in higher eukaryotes. Over a 20-year period, group II introns have been characterized first genetically, then biochemically, and finally by means of X-ray crystallography. To date, 17 crystal structures of a group II intron are available, representing five different stages of the splicing cycle. This review provides a framework for classifying and understanding these new structures in the context of the splicing cycle. Structural and functional implications for the spliceosome are also discussed. © 2013 Marcia et al.; licensee BioMed Central Ltd.
CITATION STYLE
Marcia, M., Somarowthu, S., & Pyle, A. M. (2013). Now on display: A gallery of group II intron structures at different stages of catalysis. Mobile DNA. https://doi.org/10.1186/1759-8753-4-14
Mendeley helps you to discover research relevant for your work.