Rev-erbs: Integrating metabolism around the clock

Abstract

Mammalian circadian and metabolic physiologies are intertwined, and the nuclear Rev-erbα is a key transcriptional link between them. Rev-erbα, and the highly related Rev-erbβ, are potent transcriptional repressors that are required for the function of the core mammalian molecular clock. The Rev-erbs are also critical regulators of clock output in metabolic cells and tissues. This chapter focuses on the physiological functions of Rev-erbα and β in regulating circadian rhythms and metabolism in mammalian tissues.