Aminoglycoside Pharmacodynamics

Abstract

Aminoglycosides are antimicrobial agents traditionally derived from natural sources. They exhibit potent in vitro bactericidal activity against a broad spectrum of pathogens. Over the years, the clinical use of the aminoglycosides has changed considerably. With a narrow therapeutic index, there is a need for individualized therapy based on patient specific pharmacokinetics and pathogen susceptibility, especially if prolonged therapy is indicated. With an improved understanding of resistance mechanisms, synthetic structural analogs are under clinical development. These agents could have a unique role in the management of infections due to multidrug-resistant bacteria.