Antiseizure medications for neonates with seizures

Abstract

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess whether any anti-seizure medication (ASM) is more or less effective than an alternative ASM (both ASMs used as first-, second- or third-line treatment) in achieving seizure control and improving neurodevelopmental outcomes in neonates with seizures. We will analyse EEG-confirmed seizures and clinically-diagnosed seizures separately. To assess maintenance therapy with ASM compared to no maintenance therapy after achieving seizure control. We will analyse EEG-confirmed seizures and clinically-diagnosed seizures separately. To assess any ASM treatment compared to no ASM treatment for clinically-diagnosed or only-electrographic seizures.