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Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess whether any anti-seizure medication (ASM) is more or less effective than an alternative ASM (both ASMs used as first-, second- or third-line treatment) in achieving seizure control and improving neurodevelopmental outcomes in neonates with seizures. We will analyse EEG-confirmed seizures and clinically-diagnosed seizures separately. To assess maintenance therapy with ASM compared to no maintenance therapy after achieving seizure control. We will analyse EEG-confirmed seizures and clinically-diagnosed seizures separately. To assess any ASM treatment compared to no ASM treatment for clinically-diagnosed or only-electrographic seizures.
Abiramalatha, T., Thanigainathan, S., Ramaswamy, V. V., Pressler, R., Brigo, F., & Hartmann, H. (2022, March 25). Antiseizure medications for neonates with seizures. Cochrane Database of Systematic Reviews. John Wiley and Sons Ltd. https://doi.org/10.1002/14651858.CD014967
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