Abstract
Methods of estimating allele frequencies from data on unrelated and related individuals are described in this chapter. For samples of unrelated individuals with simple codominant markers, the natural estimator of allele frequencies can be used. For genetic data on related individuals, maximum likelihood estimation (MLE) can be applied to compute allele frequencies. Factors that influence allele frequencies in populations are also explained. © 2012 Springer Science+Business Media, LLC.
Author supplied keywords
- ABO blood group
- Allele
- Allele frequency
- Disease research
- Expectation- maximization algorithm
- Families
- Founder
- Genetic drift
- Genotype
- Hardy-Weinberg equilibrium
- Log-likelihood
- Maximum likelihood estimation
- Migration
- Mutation
- Natural estimator
- Natural selection
- Nonfounder
- Nonrandom mating
- Pedigree
- Phenotype
- Population genetics
- Related individuals
- Relatives
- Unrelated individuals
Cite
CITATION STYLE
APA
Adrianto, I., & Montgomery, C. (2012). Estimating allele frequencies. Methods in Molecular Biology, 850, 59–76. https://doi.org/10.1007/978-1-61779-555-8_5
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
Already have an account? Sign in
Sign up for free