Overview of the Alzheimer's disease pathology and potential therapeutic targets

Abstract

This chapter succinctly summarizes some basic aspects of Alzheimer's disease (AD) pathology for the nonexpert reader. The objective is to provide an overview for subsequent chapters that deal with specific current and prospective AD therapeutics. The AD literature is so vast that, unavoidably, it was not possible to cover all aspects of the interesting or exciting issues under investigation. Although this chapter reflects a personal view of the field, I have tried, as much as possible, to bring ideas that have the greatest consensus to the forefront.