Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays

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Abstract

Comparing seroprevalence and antibody kinetics in three different commercially available assays for SARS-CoV-2. Serostatus of COVID-19 patients was analyzed 5 months and 10 months after their infection, using three different assays: Diasorin LIAISON, Euroimmun, Abbott Diagnostics ARCHITECT. Seropositivity at baseline differed significantly depending on the assay (Diasorin 81%, Euroimmun 83%, Abbott 59%). At follow-up antibody levels detected in the Diasorin assay were stable, while there was a significant loss in seropositivity in the Euroimmun and Abbott assays. There are significant differences in SARS-CoV-2 antibody kinetics based on the specific assay used.

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Kahre, E., Galow, L., Unrath, M., Haag, L., Blankenburg, J., Dalpke, A. H., … Armann, J. P. (2021). Kinetics and seroprevalence of SARS-CoV-2 antibodies: a comparison of 3 different assays. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-94453-5

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