Synthesis, characterization and cytotoxicity evaluation of new diphenyl sulfone derivatives

Abstract

Taking into account that the substituted diphenyl sulfone is an important pharmacophore in medicinal chemistry, in this paper, we report the synthesis, characterization, and cytotoxicity evaluation of seven new compounds: six ethyl 1,3-oxazol-5-yl carbonates and an acyclic product (ethyl ester of an N-acyl-α-amino acid), containing the arylsulfonylphenyl moiety. The synthesized compounds were characterized by elemental analysis and spectral techniques (UV-Vis, FT-IR, MS,1H-NMR,13C-NMR). Their purity was checked by reversed phase HPLC. The cytotoxic effect of new compounds was assessed using Daphnia magna bioassay.