Recent chromosome conformation capture experiments have led to the discovery of dense, contiguous, megabase-sized topological domains that are similar across cell types, are conserved across species. These domains are strongly correlated with a number of chromatin markers and have since been included in a number of analyses. However, functionally relevant domains may exist at multiple length scales. We introduce a new and efficient algorithm that is able to capture persistent domains across various resolutions by adjusting a single scale parameter. The identified novel domains are substantially different from domains reported previously and are highly enriched for insulating factor CTCF binding and histone modifications at the boundaries. © 2013 Springer-Verlag.
CITATION STYLE
Filippova, D., Patro, R., Duggal, G., & Kingsford, C. (2013). Multiscale identification of topological domains in chromatin. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 8126 LNBI, pp. 300–312). https://doi.org/10.1007/978-3-642-40453-5_23
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