The motor coordination activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by rota rod test

Abstract

The central nervous system (CNS) depressant effect is caused by the numerous sedative and hypnotic drugs that are currently used. Though in the late seventies some work was done on Withania coagulans, it is the vulnerable species not widely scattered. Therefore, it was worthy to investigate the CNS depressant activities of alcoholic extract of Withania coagulans fruits in Swiss albino mice by using rota rod test.To study the motor coordination activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by Rota Rod Test.Motor coordination was measured by using the Rota Rod Test. The CNS depressant drugs reduce the endurance time of mice on the rotating rod as they weaken the motor coordination so that mice fall early on the revolving rod. This endurance time is tested statistically among the control, standard and the test drugs.One way ANOVA was used for the statistical analysis.The endurance time in Swiss albino mice was statistically highly significantly (p-value < 0.001) associated with the alcoholic extract of Withania coagulans fruits on rota rod test.The alcoholic extract of Withania coagulans fruits established the CNS depressant activity in Swiss albino mice by rota rod test.