BIOLOGICAL IMPACT OF MELATONIN ON THE HEALING OF ALBINO RATS’ TONGUE ULCER.

Abstract

The pineal gland hormone melatonin is known to have both anti inflammatory and immunomodulatory effect. The present study assessed the effects of intraperitoneal injection of 10 mg/kg melatonin on the healing of induced tongue ulcer. 40 male albino rats were subjected to tongue ulcer using biopsy punch, group I (n=20), received daily 6% ethanol as vehicle. Group II (n=20), received daily melatonin. Specimens were taken after 1 st , 4 th , 10 th day. The histological examination revealed prominent inflammatory cells infiltrations and increased new blood vessels formation. Ultrastructural studies showed marked increase in collagen fibers synthesis. Immunohisochemical results using α smooth muscle actin indicated significant difference between two groups after 4 th days. Melatonin treatment improved the wound healing, both in terms of angiogenesis and orientation of collagen fibers. Considering our results, melatonin has powerful anti-inflammatory properties and has proven to be highly effective. Copy Right, IJAR, 2016,. All rights reserved.