This report shows the contribution of next-generation metagenomic sequencing (mNGS) as an alternative to challenging diagnostic infection in immunosuppressed individuals. Herein, we report three acute leukemia patients who developed severe invasive infections due to different etiologies: fungi, viruses, and protozoa. mNGS improved the diagnosis of the infections and provided the opportunity for adequate therapy. The mNGS is a hypothesis-free diagnostic platform, increasing potential in challenging diseases in hematological patients due to the extended diagnostic panel and the expedite access to the result.
CITATION STYLE
Garnica, M., Pierrotti, L. C., Oliveira, P. V. de, Mazzi, M., & Chebabo, A. (2021). Metagenomic next-generation sequencing (mNGS) for diagnostically challenging infectious diseases in patients with acute leukemia. Brazilian Journal of Infectious Diseases, 25(2). https://doi.org/10.1016/j.bjid.2021.101548
Mendeley helps you to discover research relevant for your work.