Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived fungus Aspergillus candidus IF10

Abstract

Three novel cytotoxic substances named prenylterphenyllin (1), 4″-deoxyprenylterphenyllin (2), and 4″-deoxyisoterprenin (3) were isolated from a cultured marine-derived fungus of Aspergillus candidus IF10 together with 4″-deoxyterprenin (4). Their chemical structures were elucidated on the basis of 2D NMR analysis. These compounds 1-4 showed cytotoxic activity against human epidermoid carcinoma KB cells (KB3-1) with IC 50 of 8.5, 3.0, 2.5, and 4.5 μg/ml, respectively. © Japan Antibiotics Research Association.