Photodynamic therapy for the treatment of metastatic lesions in bone: Studies in rat and porcine models

  • Burch S
  • Bogaards A
  • Siewerdsen J
  • et al.
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Abstract

This study represents the first reported use of photodynamic therapy (PDT) for metastatic bone lesions and specifically, as a treatment for spinal metastases. A model of bone metastasis in rat confirmed the efficacy of benzoporphyrin derivative-monoacid-mediated PDT for treating lesions within the spine and appendicular bone. Fluorimetry confirmed the selective accumulation of drug into the tumor(s) at 3 h post-injection. 48 h post-light delivery into the vertebral body of the rat spine loss of bioluminescent signal and histological analyses of sectioned spine confirmed MT-1 tumor cell kill in vivo as previously confirmed in vitro using an established cell viability assay. Porcine vertebrae provided a model comparable to that of human for light propagation and PDT response. Histological examination of vertebrae 48 h post-PDT revealed a necrotic radius of 0.6 cm with an average fluence rate of 4.3 mW/cm2. Non-necrotic tissue damage was evident up to 2 cm out from the treatment fiber. Results support the application of PDT to the treatment of primary or metastatic lesions within bone.

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Burch, S., Bogaards, A., Siewerdsen, J., Moseley, D., Yee, A., Finkelstein, J., … Bisland, S. K. (2005). Photodynamic therapy for the treatment of metastatic lesions in bone: Studies in rat and porcine models. Journal of Biomedical Optics, 10(3), 034011. https://doi.org/10.1117/1.1921887

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