Penetration of teicoplanin into serum, heart valves, and subcutaneous and muscle tissues was determined in 22 patients undergoing open-heart surgery. Each patient received 12 mg of teicoplanin per kg of body weight as a 30-min intravenous infusion preoperatively. Within 10 h, serum concentrations of teicoplanin declined from 43.1 to 2.8 μg/ml. Teicoplanin concentrations in subcutaneous tissues reached their peak of 9.2 μg/g after 2 to 3 h and decreased slowly to 2.3 μg/g after 9 to 10 h. Concentrations in muscle decreased from 8.7 μg/g to nondetectable levels. Teicoplanin concentrations in cardiac valvular tissue reached their peak of 6.1 μg/g and decreased thereafter to 1.7 μg/g. Teicoplanin concentrations in heart valves were high enough to inhibit methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci, which are known to cause postoperative wound infections and infective endocarditis.
CITATION STYLE
Frank, U. K., Schmidt-Eisenlohr, E., Mlangeni, D., Schindler, M., Hoh, A., Beyersdorf, F., & Daschner, F. D. (1997). Penetration of teicoplanin into heart valves and subcutaneous and muscle tissues of patients undergoing open-heart surgery. Antimicrobial Agents and Chemotherapy, 41(11), 2559–2561. https://doi.org/10.1128/aac.41.11.2559
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