Diagnosis and management of microscopic colitis: Current perspectives

59Citations
Citations of this article
83Readers
Mendeley users who have this article in their library.

Abstract

Collagenous colitis and lymphocytic colitis, together constituting microscopic colitis, are common causes of chronic diarrhea. They are characterized clinically by chronic nonbloody diarrhea and a macroscopically normal colonic mucosa where characteristic histopathological findings are seen. Previously considered rare, they now have emerged as common disorders that need to be considered in the investigation of the patient with chronic diarrhea. The annual incidence of each disorder is five to ten per 100,000 inhabitants, with a peak incidence in 60-to 70-year-old individuals and a predominance of female patients in collagenous colitis. The etiology and pathophysiology are not well understood, and the current view suggests an uncontrolled mucosal immune reaction to various luminal agents in predisposed individuals. Clinical symptoms comprise chronic diarrhea, abdominal pain, fatigue, weight loss, and fecal incontinence that may impair the patient's health-related quality of life. An association is reported with other autoimmune disorders, such as celiac disease, thyroid disorders, diabetes mellitus, and arthritis. The best-documented treatment, both short-term and long-term, is budesonide, which induces clinical remission in up to 80% of patients after 8 weeks' treatment. However, after successful budesonide therapy is ended, recurrence of clinical symptoms is common, and the best possible long-term management deserves further study. The long-term prognosis is good, and the risk of complications, including colonic cancer, is low. We present an update of the epidemiology, pathogenesis, diagnosis, and management of microscopic colitis. © 2014 Bohr et al.

References Powered by Scopus

Unravelling the pathogenesis of inflammatory bowel disease

3696Citations
N/AReaders
Get full text

Inflammatory bowel disease

2427Citations
N/AReaders
Get full text

European consensus on the histopathology of inflammatory bowel disease

533Citations
N/AReaders
Get full text

Cited by Powered by Scopus

European guidelines on microscopic colitis: United European Gastroenterology and European Microscopic Colitis Group statements and recommendations

155Citations
N/AReaders
Get full text

Review article: Bile acid diarrhoea - Pathogenesis, diagnosis and management

86Citations
N/AReaders
Get full text

Current concepts on microscopic colitis: Evidence-based statements and recommendations of the Spanish Microscopic Colitis Group

55Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Bohr, J., Wickbom, A., Hegedus, A., Nyhlin, N., Hörnquist, E. H., & Tysk, C. (2014, August 21). Diagnosis and management of microscopic colitis: Current perspectives. Clinical and Experimental Gastroenterology. https://doi.org/10.2147/CEG.S63905

Readers over time

‘12‘14‘15‘16‘17‘18‘19‘20‘21‘22‘23‘24‘250481216

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 21

51%

Researcher 13

32%

Professor / Associate Prof. 6

15%

Lecturer / Post doc 1

2%

Readers' Discipline

Tooltip

Medicine and Dentistry 37

77%

Nursing and Health Professions 5

10%

Agricultural and Biological Sciences 4

8%

Biochemistry, Genetics and Molecular Bi... 2

4%

Article Metrics

Tooltip
Mentions
News Mentions: 2
References: 2
Social Media
Shares, Likes & Comments: 67

Save time finding and organizing research with Mendeley

Sign up for free
0