Hemodinâmica de diferentes frações inspiradas de oxigênio em cães submetidos à infusão contínua de propofol sob ventilação espontânea

Abstract

The effects of several inspired oxygen fractions (FiO2) in hemodynamics parameters in spontaneously breathing dogs submitted to continuous infusion of propofol were evaluated. Eight adult mongrel dogs were studied and the animals underwent five anesthesias. In each procedure the patient was submitted to a different FiO2, thereby resulting in five groups, namely: G100 (FiO2 = 1), G80 (FiO2 = 0.8), G60 (FiO 2 =0.6), G40 (FiO2 = 0.4), and G20 (FiO2 = 0.21). The dose of propofol was sufficient to abolish protector reflex and ensure endotracheal intubation, followed by immediate continuous infusion of that drug (0.7mg kg-1 min-1). The initial measurement (M0) of heart rate (HR); systolic (SAP), diastolic (DAP) and mean pressure (MAP), systemic (SVR) and pulmoary vascular resistance (PVR), cardiac output (CO); central venous pressures (CVP); mean pulmonary pressure (MPAP); pulmonary capillary wedge pressure (PCWP), arterial partial pressure of oxygen (PaO 2) and carbon dioxide (PaCO2) were recorded thirty minutes after the beginning of propofol infusion. Additional recordings were performed at each 15-minute interval during 60 minutes (M15, M30, M45, and M60). Numeric data were submitted to Analysis of Variance followed by Tukey Test (P<0.05). Significant values of hemodynamic parameters were not recorded neither during the experiment period nor among the groups. In conclusion, different FiO 2 does not impair hemodynamic parameters.